Blackened Chicken Alfredo Lasagna

Category: Dinner Ideas That Actually Work

Savor the rich flavors of blackened chicken paired with a luscious, homemade alfredo sauce in these lasagna roll ups. Each noodle is filled with a creamy blend of ricotta, cream cheese, spinach, and tender, seasoned chicken, then rolled up and nestled in a bed of silky alfredo. Topped with generous layers of mozzarella and colby jack cheese, the roll ups bake to golden perfection, with bubbling edges and a hearty, enticing aroma. Make ahead friendly and perfect for gatherings, this dish delivers comfort and bold taste in every slice.

Clare Recipes
Created By Lily Chen
Updated on Fri, 08 Aug 2025 01:18:20 GMT
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A fork is being used to eat a piece of food. | lilicooks.com

If you are craving the comfort of cheesy lasagna but want something extra special, this blackened chicken alfredo lasagna roll up recipe delivers bold flavor and creamy texture every time. Each rolled noodle is stuffed with a luscious cheese mixture, juicy cajun-spiced chicken, and fresh spinach, then blanketed in a garlicky homemade alfredo sauce and baked until bubbling. It is perfect for impressing guests or making a cozy family dinner feel like a treat.

I first made this when my parents visited one winter and we needed a hearty meal that still impressed. They loved the touch of spice from the cajun seasoning and now it is my go-to comfort bake for friends.

Ingredients

  • Lasagna noodles: Wide pasta sheets hold lots of rich filling and are easy to roll Choose noodles that hold together well when boiled
  • Chicken breasts or thighs: Both work for this filling Use fresh chicken for juiciness and flavor
  • Olive oil: For coating chicken and building a beautiful golden crust Choose extra virgin for depth
  • Cajun seasoning: Adds a smoky spicy kick to the chicken and filling Freshly mixed herbs and spices boost flavor Use store-bought or blend your own
  • Butter: Base for the alfredo sauce Use real butter for best texture
  • Fresh garlic: Essential for fragrant creamy sauce Use large cloves from firm fresh bulbs
  • Heavy whipping cream: Makes the alfredo luxuriously thick and rich
  • Parmesan cheese: Gives nutty salty depth to the sauce and topping Buy in a block and grate yourself for best taste
  • Salt and black pepper: To highlight all the savory flavors in the dish
  • Cream cheese and ricotta: For the filling these make it creamy and luscious Ricotta should be whole milk for the richest taste and smooth texture
  • Frozen chopped spinach: Offers freshness and color Be sure to thaw and squeeze dry fully
  • Mozzarella cheese: Melts beautifully for gooey texture Use whole milk mozzarella and shred it at home if you can
  • Colby jack cheese: Adds a creamy and sharp note to the cheese mix Always shred your own for the best melt
  • Onion powder cayenne paprika brown sugar dried thyme and oregano: Used in the blackened cajun spice blend for bold authentic flavor Check your spices are fresh and aromatic

Step-by-Step Instructions

Cook the Chicken:
Prepare your chicken by pounding each breast or thigh to a quarter inch thickness for even cooking. Rub every piece thoroughly with olive oil and coat generously with cajun seasoning. Heat a large skillet over medium heat add olive oil and lay in the chicken. Let it cook undisturbed for three to four minutes so a nice crust forms then flip once and turn the heat to low. Cook for another three minutes to finish. Cover the chicken loosely with foil and let it rest for five to ten minutes before dicing into bite-sized pieces. Resting keeps the chicken tender and juicy.
Make the Alfredo Sauce:
In the same skillet without cleaning it add butter over medium low heat. Let it melt and scrape up the flavorful bits left from the chicken. Add minced garlic and stir just until it is fragrant about one minute. Slowly whisk in heavy cream letting it heat gently and thicken for about five minutes. Add a teaspoon of cajun seasoning salt and pepper whisking well. Now stir in grated parmesan cheese letting it melt in so the sauce becomes creamy and just coats the back of your spoon. Turn off the heat and keep it warm while you prepare other steps.
Prepare the Filling:
Boil lasagna noodles to al dente following the instructions on the package. Meanwhile add softened cream cheese ricotta cheese spinach cajun seasoning diced chicken and half of both shredded cheeses to a large bowl. Mix thoroughly until everything is evenly combined. This should be a scoopable mixture for filling.
Assemble and Bake Lasagna Roll Ups:
Drain noodles and separate them right away so they do not stick. Spoon a cup of alfredo sauce over the bottom of your greased casserole pan. Lay noodles flat on a clean surface. Scoop about half a cup of the filling onto the end of each noodle and roll up tightly. Place each roll seam-side down in the dish side by side. Repeat until you have filled the pan. Pour the remaining alfredo sauce evenly over the rolls making sure every piece is covered. Sprinkle the rest of your shredded cheeses right over the top. Bake uncovered at 375 degrees for about thirty five minutes until bubbling and golden around the edges. Let rest briefly before serving.
A fork is being used to eat a piece of food. Save
A fork is being used to eat a piece of food. | lilicooks.com

My favorite part of this dish is the homemade cajun seasoning I make in a big batch and sprinkle it on everything from roasted veggies to popcorn. One year my son insisted on adding extra parmesan and we have never looked back that golden cheesy top is now a family must.

Storage Tips

These roll ups store beautifully Make sure they cool completely before covering tightly and refrigerating Leftovers will keep for up to four days Freeze individual portions wrapped well and thaw overnight in the fridge before reheating For best results reheat in the oven covered with foil to keep things moist

Ingredient Substitutions

If you prefer turkey or rotisserie chicken use that The filling also works with kale instead of spinach If you do not have colby jack try all mozzarella plus a bit of sharp cheddar Cottage cheese is a good stand in for ricotta if needed

A close up of a delicious blackened chicken Alfredo lasagna roll up. Save
A close up of a delicious blackened chicken Alfredo lasagna roll up. | lilicooks.com

Serving Suggestions

Serve each roll with a side of simple salad and maybe some garlic bread or Texas toast People love spooning a bit of extra alfredo from the bottom of the pan over each portion A sprinkle of fresh parsley or basil brings color and a little extra fragrance

Cultural and Historical Context

Lasagna itself has roots in medieval Italy but rolling up the noodles instead of layering them is a fun modern American twist that helps with portioning and adds a little wow at the table Blackened chicken and cajun seasoning draw from Louisiana cuisine and when paired with cheesy pasta it is the ultimate comfort fusion

Recipe FAQs

→ What makes the chicken blackened?

The chicken is coated with Cajun spices and seared at high heat, creating a flavorful, charred crust that adds smokiness to each bite.

→ Can I use rotisserie chicken instead?

Yes, rotisserie chicken works as a convenient substitute. Add Cajun seasoning before assembling for extra flavor.

→ Is fresh spinach possible instead of frozen?

Fresh spinach can be used—simply sauté it first to reduce moisture before mixing with the cheeses.

→ How do I keep the roll ups from sticking?

Separate cooked noodles immediately after draining, and spread a bit of sauce in the baking dish to prevent sticking.

→ Can this dish be assembled ahead of time?

Absolutely. Assemble up to a day in advance, cover tightly, and refrigerate. Bake just before serving for best results.

Blackened Chicken Alfredo Lasagna

Blackened chicken, creamy alfredo, spinach, and cheese rolled in lasagna sheets for a golden, comforting dish.

Preparation Time
30 min
Cooking Time
35 min
Overall Time
65 min
Created By: Lily Chen

Category: Main Dishes

Skill Level: Moderate

Cuisine Type: Italian-American

Output: 6 Serves (12 lasagna roll-ups)

Dietary Options: ~

Ingredients

→ Main Ingredients

01 12 lasagna noodle sheets
02 3 chicken breasts or thighs (cutlets or tenders also work)
03 4 tablespoons olive oil
04 2 tablespoons cajun seasoning
05 Garlic bread or Texas toast (optional, for serving)

→ Alfredo Sauce

06 6 tablespoons butter
07 6-8 large garlic cloves, minced
08 2 cups heavy whipping cream
09 1-2 teaspoons cajun seasoning
10 1 cup grated parmesan cheese
11 Salt and pepper to taste

→ Lasagna Filling

12 4 ounces cream cheese, softened (half a block)
13 15 ounces ricotta cheese
14 12 ounces frozen chopped spinach, well drained
15 2-3 teaspoons cajun seasoning
16 Prepared chicken, diced
17 8 ounces mozzarella cheese, shredded (divided)
18 8 ounces colby jack cheese, shredded (divided)

→ Blackened Cajun Seasoning

19 2 tablespoons smoked paprika (or regular paprika)
20 1 tablespoon cayenne pepper
21 1 tablespoon onion powder
22 2 teaspoons brown sugar
23 2 teaspoons garlic powder
24 1 teaspoon ground black pepper
25 1 teaspoon salt
26 1/2 teaspoon dried thyme
27 1/2 teaspoon dried oregano

Steps

Step 01

Preheat oven to 375°F (190°C) and grease a 9x13-inch baking dish.

Step 02

Pound chicken breasts to an even 1/4-inch thickness. Rub chicken with olive oil and season liberally with cajun seasoning. Heat a skillet over medium heat, add 2 tablespoons olive oil, and cook chicken 3-4 minutes on one side, then flip and cook on low for an additional 3 minutes. Let rest under tented foil for 5-10 minutes, then dice.

Step 03

In the same pan over medium-low heat, melt butter. Add garlic and stir until fragrant, about 1 minute. Gradually whisk in heavy cream and simmer for 5 minutes. Add 1 teaspoon cajun seasoning, salt, and pepper to taste. Whisk in parmesan cheese until melted and thickened, about 3 minutes, then remove from heat.

Step 04

Cook lasagna noodles according to package instructions to al dente. In a large bowl, mix cream cheese, ricotta, cajun seasoning, spinach, diced chicken, and half of the shredded cheeses to create the filling.

Step 05

Drain noodles and separate them to prevent sticking. Spread 1 cup of alfredo sauce in the bottom of the greased baking dish. Lay noodles flat and add about 1/2 cup of filling to one end of each sheet. Roll tightly and place seam-side down into the dish.

Step 06

Pour remaining alfredo sauce evenly over the rolls, spooning excess sauce back on top. Sprinkle the remaining shredded cheese evenly over the rolls. Bake uncovered for 35 minutes or until golden and bubbling.

Tips

  1. Ensure the spinach is well-drained to prevent excess moisture in the filling.
  2. Allow the chicken to rest before dicing to retain its juices.

Required Tools

  • 9x13-inch baking dish
  • Large skillet
  • Mixing bowl
  • Whisk
  • Pot for cooking noodles

Allergy Information

Always check each ingredient for allergens, and consult a medical professional if unsure.
  • Contains dairy (cheese, butter, cream)
  • Contains gluten (lasagna noodles)
  • Contains garlic

Nutritional Information (per serving)

These details are shared for general guidance and don’t replace professional advice.
  • Calories: 640.5
  • Fats: 38.4 g
  • Carbohydrates: 42.3 g
  • Proteins: 37.8 g